PLEASE Read the instructions closely! In preclinical research, animal models pro

PLEASE Read the instructions closely!
In preclinical research, animal models provide a critical step in the research process for both understanding the etiology of disease as well as a mechanism for discovery and validation of new therapeutic targets. The animal model assigned to be studied in this paper is PARKIN Mouse.
Please include the following aspects in this research paper:
o What is the rationale for the development of the model in terms of the genes or toxins used.
o What is the rationale for the species used to generate the model?
o Describe disease relevant pathophysiology.
o How was the model constructed?
o Describe the model in terms of its validity (face, construct predictive)
o How has the model been utilized in terms of understanding the etiology of disease, mechanisms of neurodegeneration, or the development of pharmacological and nonpharmacological therapy? Provide an example.
o Describe the strengths and limitations of the model. How would you propose to improve the model?
o What are your thoughts on the model, its potential in therapeutic development, and future directions or impact?
Document Guidelines:
• Font 11 pt. Arial or Time New Roman.
• Spacing 1.5 per line.
• 0.5 in margins all around.
• Number each page.
• Proper citations indicated as [3] in the text.
• Target at least 10 citations. Focus on primary research articles in the text of this written assignment but review articles can be used to give yourself some background and general ideas.
• Utilize Figures
• Organize with the aid of subtitles.
• Develop well organized Introduction, Background, Conclusions.
• Provide a 100 word Abstract at the beginning of the article.
• Make it interesting.